| ncRNA name | hsa-miR-488-3p |
| ncRNA Category | miRNA |
| Disease name | retinoblastoma (RB) |
| Species | Homo sapiens |
| Tissues/Cell_line | RB samples, normal retinas; RB cell lines SO-RB50, WERI-Rb1, Y79 and HXO-RB44; RPE cell line ARPE-19 |
| Methods | transfection, qPCR, CCK-8 assay, transwell assay, EdU assay, cell cycle assay, TUNEL assay, luciferase reporter assay, Western blot |
| Expression pattern | down-regulated |
| Functional description | MiR-488-3p expression was downregulated in RB tissues and cell lines. The analysis of the mechanisms of action revealed that the reduction of PVT1 inhibited the expression of notch2 by upregulating miR-488-3p. |
| PubMed ID | 30797143 |
| Year | 2019 |
| Title | Knockdown of lncRNA PVT1 inhibits retinoblastoma progression by sponging miR-488-3p. |
| Drug-related ncRNA | NO |
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